Blood-stage dynamics and clinical implications of mixed Plasmodium vivax-Plasmodium falciparum infections.

摘要: We present a mathematical model of the blood-stage dynamics mixed Plasmodium vivax-Plasmodium falciparum malaria infections in humans. The reproduces features such found nature and suggests several phenomena that may merit clinical attention, including potential recrudescence long-standing, low-level P. infection following vivax or relapse capacity an existing to reduce peak parasitemia superinfection. simulate administration antimalarial drugs, illustrate some complications treating mixed-species infections. Notably, our indicates when is misdiagnosed as single-species infection, treatment for can lead surge parasitemia.