Cardiac cycle-dependent changes in aortic area and distensibility are reduced in older patients with isolated diastolic heart failure and correlate with exercise intolerance☆

摘要: OBJECTIVES The goal of this study was to determine if cardiac cycle-dependent changes in proximal thoracic aortic area and distensibility are associated with exercise intolerance elderly patients diastolic heart failure (DHF). BACKGROUND Aortic compliance declines substantially age. We hypothesized that a reduction (above which occurs aging) could be the is prominent patients. METHODS Thirty subjects (20 healthy individuals [10 60 years age] 10 > age DHF) underwent magnetic resonance imaging (MRI) aorta followed within 48 h by maximal ergometry expired gas analysis. RESULTS The DHF had higher resting brachial pulse systolic blood pressure, left ventricular mass, wall thickness mean flow velocity, and, compared older subjects, they significant MRI-assessed change (p < 0.0001) correlated diminished peak oxygen consumption (r = 0.79). After controlling for gender multivariate analysis, predictor 0.04). CONCLUSIONS Older isolated have reduced (beyond normal aging), correlates may contribute their severe intolerance.