Functional characterization of BRCA1 and BRCA2: clues from their interacting proteins.
作者： Shyam K. Sharan , Allan Bradley
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摘要: The familial breast and ovarian cancersusceptibility genes, BRCA1 BRCA2 have been thesubject of extensive functional analysis studies sincetheir cloning. Clues to their biological role inmaintaining the genomic integrity were provided by studiesthat revealed interaction with recombinationrepair protein HsRad51. first clue an interactionbetween HsRad51 came from colocalization characteristic nuclear foci formed bythese two proteins during S phase cell cycle. Aninteraction between murine Brca2 MmRad51 wasdetected yeast hybrid system. Utilizing system other techniquesseveral Brca1 interacting havebeen identified like, BARD1, importin-α, BIPs, RNApolymerase II holoenzyme, BRAP2 etc. Recently, mutations suggesting a as tumorsuppressor in BARD1 gene inprimary human tumors. identification moleculesthat interact has greatly enhanced our knowledge how mayfunction tumor suppressors.
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