Helicobacter pylori-secreting protein Tipα is a potent inducer of chemokine gene expressions in stomach cancer cells

作者: Takashi Kuzuhara , Masami Suganuma , Miki Kurusu , Hirota Fujiki

DOI: 10.1007/S00432-006-0169-6

关键词:

摘要: Purpose Stomach cancer has a high mortality rate in East Asia, and is strongly associated with Helicobacter pylori (H. pylori) infection. H.pylori known to express chemokine genes the gastric mucosa, chemokines that are important host immune factors facilitating inflammation tumor growth. To investigate mechanism of carcinogenesis stomach, it essential determine which molecule H. involved induction chemokines, but this remained unclear. We previously reported necrosis factor-α (TNF-α) inducing protein (Tipα) secreted from acts as promoter stomach development, thus started whether Tipα genes.

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