Glycoprotein 130 promotes human blastocyst development in vitro
作者： Fredwell Hambiliki , Jörg Hanrieder , Jonas Bergquist , Julius Hreinsson , Anneli Stavreus-Evers
DOI: 10.1016/J.FERTNSTERT.2012.12.041
关键词:
摘要: Objective: To investigate the efficacy of leukemia inhibitory factor (LIF) and/or glycoprotein 130 Design: Laboratory study. Setting: University hospital-based IVF clinic. Patient(s): A total 164 frozen embryos that survived thawing were cultured in media supplemented Intervention(s): Morphological development was evaluated by light microscopy. Protein expression Main Outcome Measure(s): Embryo and protein content. Result(s): Addition gp130 to culture improved blastocyst formation (73% vs. 43%). Conclusion(s): Glycoprotein 130, but not LIF, seems be beneficial for preimplantation embryo
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