Recent trials in critical care nephrology.

作者: Rinaldo Bellomo , Paul M. Palevsky , Sean M. Bagshaw , Noel Gibney , Finlay A. McAlister

DOI: 10.1159/000313770

关键词:

摘要: Several large observational studies or randomized controlled trials in the field of critical care nephrology have been completed and reported, recently begun recruitment. These provide important information to guide our appreciation current practice consider new potentially effective intervention for prevention attenuation acute kidney injury suggest avenues use renal replacement therapy (RRT) treatment sepsis. In particular, two studies, ATN study RENAL (both multicenter > 1,000 patients) provide, first time, level I evidence RRT critically ill patients better define optimal intensity such this setting. Clinicians practicing need be aware these trials, their details, findings design recruitment rate likely time completion continue offer highest evidence-based medical care.

参考文章(11)
C Ronco, R Bellomo, Renal replacement therapy in the intensive care unit. Critical Care and Resuscitation. ,vol. 1, pp. 13- 24 ,(1999)
Intensity of continuous renal-replacement therapy in critically ill patients. The New England Journal of Medicine. ,vol. 361, pp. 1627- 1638 ,(2009) , 10.1056/NEJMOA0902413
Simon Finfer, Alan Cass, Martin Gallagher, Joanne Lee, Steve Su, Rinaldo Bellomo, RENAL Study Investigators, None, The RENAL (Randomised Evaluation of Normal vs. Augmented Level of Replacement Therapy) study: statistical analysis plan Critical Care and Resuscitation. ,vol. 11, pp. 58- 66 ,(2009)
Dinna N. Cruz, Massimo Antonelli, Roberto Fumagalli, Francesca Foltran, Nicola Brienza, Abele Donati, Vincenzo Malcangi, Flavia Petrini, Giada Volta, Franco M. Bobbio Pallavicini, Federica Rottoli, Francesco Giunta, Claudio Ronco, Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock JAMA. ,vol. 301, pp. 2445- 2452 ,(2009) , 10.1001/JAMA.2009.856
Didier Payen, Joaquim Mateo, Jean Marc Cavaillon, François Fraisse, Christian Floriot, Eric Vicaut, Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: A randomized controlled trial* Critical Care Medicine. ,vol. 37, pp. 803- 810 ,(2009) , 10.1097/CCM.0B013E3181962316
Intensity of renal support in critically ill patients with acute kidney injury The New England Journal of Medicine. ,vol. 359, pp. 7- 20 ,(2008) , 10.1056/NEJMOA0802639
Patrick M. Honore, Olivier Joannes-Boyau, Willem Boer, Vincent Collin, High-volume hemofiltration in sepsis and SIRS: current concepts and future prospects. Blood Purification. ,vol. 28, pp. 1- 11 ,(2009) , 10.1159/000210031
Michael Haase, Anja Haase-Fielitz, Rinaldo Bellomo, Prasad Devarajan, David Story, George Matalanis, Michael C. Reade, Sean M. Bagshaw, Narelle Seevanayagam, Siven Seevanayagam, Laurie Doolan, Brian Buxton, Duska Dragun, Sodium bicarbonate to prevent increases in serum creatinine after cardiac surgery: a pilot double-blind, randomized controlled trial. Critical Care Medicine. ,vol. 37, pp. 39- 47 ,(2009) , 10.1097/CCM.0B013E318193216F
Michael Haase, Rinaldo Bellomo, Prasad Devarajan, Peter Schlattmann, Anja Haase-Fielitz, NGAL Meta-analysis Investigator Group, None, Accuracy of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Diagnosis and Prognosis in Acute Kidney Injury: A Systematic Review and Meta-analysis American Journal of Kidney Diseases. ,vol. 54, pp. 1012- 1024 ,(2009) , 10.1053/J.AJKD.2009.07.020