Blood Purification in Sepsis and Acute Kidney Injury in Critically III Patients

摘要: Despite major advances in blood purification therapies, numerous questions remain. As a result, clinicians may still have some hesitation regarding the real efficacy of these techniques sepsis as well best mode hemofiltration therapy when treating patients with septic shock plus acute kidney injury (AKI) [1]. However, despite recent therapeutic improvements, remains leading cause mortality intensive care [2]. In addition, according to latest available literature, it is paramount importance realize that rate AKI much higher compared non-septic [3], [4]. last decade, several milestone studies [5], [6] shown dose important terms mortality, although so-called negative trials challenged this concept. Nevertheless, critical desirable and beyond dose, will be affected [7], [8]. We should not forget, however, carry very limitations [9], [10]. Regarding specifically rationale, seems at least theoretically reasonable effectively removing mediators from tissue, where they are harmful, transporting them central circulation must effective. Effectiveness through only passive transportation mechanism elusive. Indeed, surface compartment about 30 m2, which smaller than capillary compartment, 300 m2 [11], so transport between two asymmetric compartments yield same elimination on both sides.