The presence in normal serum of specific antibody against bacteriophage T4 and its increase during the earliest stages of immunization.

摘要: Summary 1.The sera of normal animals contain minute amounts a specific antibody A which can act on T4 bacteriophage. The relative concentrations in different be precisely measured.The concentration the blood an animal may increased by factor 100 within 4 days after stimulating with single injection antigen. It is not immunization unrelated antigens.On phage production precedes T4-inactivating antibodies time, and thus provides means investigating early stages response to antigen stimulus. 2.Antibody reveals its presence permanently activating particles certain strains are reversibly activated tryptophane other cofactors.The kinetics activation suggest following points concerning mechanism. Structures at each about five sites particle oscillate independently between two states. become active when all simultaneously positive state. Antibody A, tryptophane, indole only individual sites, retarding or precipitating their relapse into negative