Interleukin-20 circulating levels in obese women: Effect of weight loss

摘要: Abstract Background and aims Obesity is associated with an increased risk of developing atherosclerosis. Interleukin-20 (IL-20) a pleiotropic cytokine thought to be involved in the onset progression The aim this study was determine whether circulating levels IL-20 are elevated obese women they could affected by substantial decrease body weight. Methods results Fifty 50 age-matched, normal weight, premenopausal participated study. Obese entered into medically supervised weight loss program aimed at reducing 90% baseline. We measured anthropometric, glucose lipid parameters, IL-20, C-Reactive Protein (CRP) interleukin-10 (IL-10) levels. Circulating CRP were significantly higher than control (P = 0.01), while IL-10 lower; positively (r = 0.35; P = 0.02) visceral fat (waist–hip ratio; r = 0.32; P = 0.025). Caloric restriction-induced (>10% original weight) over 6 months reduced from 152 (112/184) 134 (125/153) pg/ml (median 25%/75%; P = 0.03), it changes mass index waist–hip ratio. Conclusion In women, matched ratio, loss.