Fatty acid α-hydroxylation and its relation to myelination

作者: Yasuo Kishimoto , Hiroshi Akanuma , Inderjit Singh

DOI: 10.1007/BF00223361

关键词:

摘要: α-Hydroxylation is an enzymatic reaction by which long-chain fatty acids are converted to their α-hydroxy derivatives. This reaction, in animals, can be detected only developing brain and the rate-determining step synthesis of hydroxycerebroside, indispensable abundant myelin lipid. In addition a particulate fraction from brain, two cytoplasmic factors, one heat-stable other heat-labile, required for α-hydroxylation. During past eight years we have been investigating Our progress summarized discussed here.

参考文章(36)
W.E. Shine, P.K. Stumpf, Fat metabolism in higher plants Archives of Biochemistry and Biophysics. ,vol. 162, pp. 147- 157 ,(1974) , 10.1016/0003-9861(74)90113-1
Gabriel M. Levis, James F. Mead, An α-Hydroxy Acid Decarboxylase in Brain Microsomes Journal of Biological Chemistry. ,vol. 239, pp. 77- 80 ,(1964) , 10.1016/S0021-9258(18)51748-8
James F. Mead, Gabriel M. Levis, A 1 carbon degradation of the long chain fatty acids of brain sphingolipids. Journal of Biological Chemistry. ,vol. 238, pp. 1634- 1636 ,(1963) , 10.1016/S0021-9258(18)81113-9
Armand J. Fulco, James F. Mead, The biosynthesis of lignoceric, cerebronic, and nervonic acids. Journal of Biological Chemistry. ,vol. 236, pp. 2416- 2420 ,(1961) , 10.1016/S0021-9258(18)64013-X
Albert Charles Chibnall, Stephen Harvey Piper, Ernest Frank Williams, The fatty acids of phrenosin and kerasin1 Biochemical Journal. ,vol. 30, pp. 100- 114 ,(1936) , 10.1042/BJ0300100
Yasuo Kishimoto, [31] Very long chain fatty acid α-hydroxylase from brain Methods in Enzymology. ,vol. 52, pp. 310- 318 ,(1978) , 10.1016/S0076-6879(78)52033-8
Armand J. Fulco, Chain Elongation, 2-Hydroxylation, and Decarboxylation of Long Chain Fatty Acids by Yeast Journal of Biological Chemistry. ,vol. 242, pp. 3608- 3613 ,(1967) , 10.1016/S0021-9258(18)95852-7
S Murad, R H Chen, Y Kishimoto, alpha-Hydroxylation of fatty acids in brain. Substrate specificity and deuterium isotope effect. Journal of Biological Chemistry. ,vol. 252, pp. 5206- 5210 ,(1977) , 10.1016/S0021-9258(19)63332-6