CYTOTOXICITY OF DAUNORUBICIN IN TRISOMIC (+21) HUMAN FIBROBLASTS: RELATION TO DRUG UPTAKE AND CELL MEMBRANE FLUIDITY
作者： Maria Przybylska , Aneta Koceva‐Chyla , Blazej Rózga , Zofia Józwiak
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摘要: The influence of daunorubicin (DNR) on survival human normal (S-126) and trisomic, with respect to chromosome 21 (T-164; S-240), skin fibroblasts some parameters related it, such as intracellular drug accumulation, distribution interaction cell membrane, were studied. in vitro growth-inhibition assay indicated that DNR was less cytotoxic for trisomic than cells. Comparison kinetic this compound showed the uptake amount free greater Contrary this, there no significant differences between DNA-bound both types TMA-DPH 12-AS fluorescence anisotropy measurements demonstrated decreased lipid fluidity inner hydrophobic region plasma membrane types, but did not outer surface membrane. We conclude derived from individuals affected Down's syndrome are better protected damage induced by
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