Involvement of reactive oxygen species in aclarubicin-induced death of human trisomic and diabetic fibroblasts.
作者： Katarzyna Kania , Aneta Zych , Zofia Jóźwiak
DOI: 10.1016/J.TIV.2007.02.013
关键词:
摘要: We investigated the mode of cell death induced by aclarubicin in human trisomic and diabetic fibroblasts. The cells were incubated with for 2 h then cultured drug-free medium up to 96 h. Aclarubicin fibroblasts, compared normal cells, lesser changes level reactive oxygen species (ROS) content intracellular calcium. drug ROS-mediated apoptotic necrotic pathways all lines. extent apoptosis necrosis was strongly dependent on line, sensitivity post-treatment time. These results indicate that most resistant died prevalently apoptosis. In case number decreased post-incubation role aclarubicin-induced confirmed diminution effects antioxidants (N-acetylcysteine pyrrolidine-dithiocarbamate) drug-induced ROS formation, increase calcium fibroblast
elsevier.com
sci-hub.se 参考文章(43)
Judy B. De Haan, Ernst J. Wolvetang, Francesca Cristiano, Rocco Iannello, Cecile Bladier, Michael J. Kelner, Ismail Kola, Reactive oxygen species and their contribution to pathology in Down syndrome. Advances in pharmacology. ,vol. 38, pp. 379- 402 ,(1996) , 10.1016/S1054-3589(08)60992-8
Jesús E. Paz-Miguel, Pablo Sánchez-Velasco, Gonzalo Ocejo-Vinyals, Jacobo López de Rego, Reyes Flores, Juan Escribano de Diego, Francisco Leyva-Cobián, Reactive oxygen intermediates during programmed cell death induced in the thymus of the Ts(1716)65Dn mouse, a murine model for human Down's syndrome. Journal of Immunology. ,vol. 163, pp. 5399- 5410 ,(1999)
Zofia Jóźwiak, Sylwia Dragojew, Katarzyna Kania, Morphological and biochemical changes in human fibroblast lines induced by anthracyclines during apoptosis. Cellular & Molecular Biology Letters. ,vol. 8, pp. 121- ,(2003)
Barry Halliwell, John M.C. Gutteridge, Role of free radicals and catalytic metal ions in human disease: an overview. Methods in Enzymology. ,vol. 186, pp. 1- 85 ,(1990) , 10.1016/0076-6879(90)86093-B
John D. Hayes, Lesley I. McLellan, Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress Free Radical Research. ,vol. 31, pp. 273- 300 ,(1999) , 10.1080/10715769900300851
Krzysztof J. Reszka, Michael L. McCormick, Bradley E. Britigan, Peroxidase-and nitrite-dependent metabolism of the anthracycline anticancer agents daunorubicin and doxorubicin Biochemistry. ,vol. 40, pp. 15349- 15361 ,(2001) , 10.1021/BI011869C
G. Romeo, W.-H. Liu, V. Asnaghi, T. S. Kern, M. Lorenzi, Activation of Nuclear Factor-κB Induced by Diabetes and High Glucose Regulates a Proapoptotic Program in Retinal Pericytes Diabetes. ,vol. 51, pp. 2241- 2248 ,(2002) , 10.2337/DIABETES.51.7.2241
Maria Przybylska, Aneta Koceva‐Chyla, Blazej Rózga, Zofia Józwiak, CYTOTOXICITY OF DAUNORUBICIN IN TRISOMIC (+21) HUMAN FIBROBLASTS: RELATION TO DRUG UPTAKE AND CELL MEMBRANE FLUIDITY Cell Biology International. ,vol. 25, pp. 157- 170 ,(2001) , 10.1006/CBIR.2000.0583
Jorge Busciglio, Bruce A. Yankner, Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro Nature. ,vol. 378, pp. 776- 779 ,(1995) , 10.1038/378776A0
Hideki Mizutani, Saeko Tada-Oikawa, Yusuke Hiraku, Michio Kojima, Shosuke Kawanishi, Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide Life Sciences. ,vol. 76, pp. 1439- 1453 ,(2005) , 10.1016/J.LFS.2004.05.040