pol Gene Sequence Variation in Swedish HIV-2 Patients Failing Antiretroviral Therapy

摘要: There is limited knowledge about how to treat and interpret results from genotypic resistance assays in HIV-2 infection. Here, genetic variation pol gene was studied 20 of 23 known cases Sweden. Five patients with signs virological treatment failure were longitudinally studied. Clinical, immunological data collected the protease (PR) first half reverse transcriptase (RT) amplified directly sequenced plasma samples. Moderate extensive evolution observed four five who failed treatment. Some mutations occurred at positions confer HIV-1, but many other PR RT. All had been treated zidovudine alone or combination antiretroviral drugs, none displayed a mutation position 215, which primary site HIV-1. Instead, E219D evolved virus two Q151M patients. A M184V indicative lamivudine detected three The one patient ritonavir, nelfinavir, lopinavir successively acquired nine unusual gene, most are not considered secondary Our indicate that evolutionary pathways lead HIV-1 exhibit both similarities differences. Genotypic cannot be interpreted using algorithms developed for instead new specific have developed.