Blaming the Brain for Obesity: Integration of Hedonic and Homeostatic Mechanisms

摘要: The brain plays a key role in the controls of energy intake and expenditure, many genes associated with obesity are expressed central nervous system. Technological conceptual advances both basic clinical neurosciences have expanded traditional view homeostatic regulation body weight by mainly hypothalamus to include hedonic appetite cortical subcortical areas processing external sensory information, reward, cognition, executive functions. Hedonic interact regulate flexible adaptive manner that takes environmental conditions into account. This new framework has several important implications for treatment obesity. Because much this interactive neural is outside awareness, cognitive restraint world plenty made difficult prevention should be more rationally directed complex often redundant mechanisms underlying interaction.