Singing Mice, Songbirds, and More: Models for FOXP2 Function and Dysfunction in Human Speech and Language
作者： S. A. White , S. E. Fisher , D. H. Geschwind , C. Scharff , T. E. Holy
DOI: 10.1523/JNEUROSCI.3379-06.2006
关键词:
摘要: In 2001, a point mutation in the forkhead box P2 (FOXP2) coding sequence was identified as basis of an inherited speech and language disorder suffered by members family known “KE.” This mini-symposium review focuses on recent findings research-in-progress, primarily from five laboratories. Each aims at capitalizing FOXP2 discovery to build neurobiological bridge between molecule phenotype. Below, we describe genetic through behavioral techniques used currently investigate FoxP2 birds, rodents, humans for neural bases vocal learning language.
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Zoltan Molnar, G Bock, Development of the cerebral cortex J. Wiley. ,(1995)
Richard A. Zann, The Zebra Finch: A Synthesis of Field and Laboratory Studies ,(1996)
Bing Ren, Brian D Dynlacht, Use of Chromatin Immunoprecipitation Assays in Genome-Wide Location Analysis of Mammalian Transcription Factors Chromatin and Chromatin Remodeling Enzymes, Part B. ,vol. 376, pp. 304- 315 ,(2003) , 10.1016/S0076-6879(03)76020-0
Susan K. McConnell, Chapter 12 Plasticity and commitment in the developing cerebral cortex Progress in Brain Research. ,vol. 105, pp. 129- 143 ,(1995) , 10.1016/S0079-6123(08)63290-2
Kay D. MacDermot, Elena Bonora, Nuala Sykes, Anne-Marie Coupe, Cecilia S.L. Lai, Sonja C. Vernes, Faraneh Vargha-Khadem, Fiona McKenzie, Robert L. Smith, Anthony P. Monaco, Simon E. Fisher, Identification of FOXP2 Truncation as a Novel Cause of Developmental Speech and Language Deficits American Journal of Human Genetics. ,vol. 76, pp. 1074- 1080 ,(2005) , 10.1086/430841
W. Shu, J. Y. Cho, Y. Jiang, M. Zhang, D. Weisz, G. A. Elder, J. Schmeidler, R. De Gasperi, M. A. G. Sosa, D. Rabidou, A. C. Santucci, D. Perl, E. Morrisey, J. D. Buxbaum, Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 9643- 9648 ,(2005) , 10.1073/PNAS.0503739102
Cecilia SL Lai, Dianne Gerrelli, Anthony P Monaco, Simon E Fisher, Andrew J Copp, FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder. Brain. ,vol. 126, pp. 2455- 2462 ,(2003) , 10.1093/BRAIN/AWG247
P. Rakic, Radial versus tangential migration of neuronal clones in the developing cerebral cortex Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 11323- 11327 ,(1995) , 10.1073/PNAS.92.25.11323
Cecilia S. L. Lai, Simon E. Fisher, Jane A. Hurst, Faraneh Vargha-Khadem, Anthony P. Monaco, A forkhead-domain gene is mutated in a severe speech and language disorder Nature. ,vol. 413, pp. 519- 523 ,(2001) , 10.1038/35097076
CONSTANCE SCHARFF, STEPHANIE A. WHITE, Genetic components of vocal learning. Annals of the New York Academy of Sciences. ,vol. 1016, pp. 325- 347 ,(2004) , 10.1196/ANNALS.1298.032