Dietary intakes of α-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men

摘要: Investigations suggest a protective role of n-3 polyunsaturated fatty acids (PUFA) but opposing roles n-6 PUFA in inflammation, the effects vivo human are not clear. We therefore tested hypothesis that higher intakes and associated with lower levels inflammation among population consuming diet high PUFA. This study aimed to assess association between intake serum C-reactive protein (CRP) concentrations group Japanese employees. The subjects were 300 men 211 women aged 21 67 years working 2 municipal offices Japan. measured high-sensitivity CRP by latex agglutination nephelometry method assessed dietary habits validated self-administered history questionnaire. analyzed data using multiple linear regression analysis adjustment for potential confounding variables. Mean tended decrease as eicosapentaenoic acid, docosahexaenoic or their combination increased women, although none these relationships was statistically significant. In men, there significant inverse (P trend = .03 .008, respectively). Among specific PUFA, only alpha-linolenic acid linoleic showed clear .001 .003, respectively) men. results (n-3 PUFA) also (n-6 has beneficial effect on systemic