Characterization and assessment of hyperelastic and elastic properties of decellularized human adipose tissues.

摘要: Abstract Decellularized adipose tissue (DAT) has shown potential as a regenerative scaffold for plastic and reconstructive surgery to augment or replace damaged missing (e.g. following lumpectomy mastectomy). The mechanical properties of soft substitutes are paramount importance in restoring the natural shape appearance affected tissues, mismatching can lead unpredictable scar formation poor implant integration. goal this work was assess linear elastic hyperelastic decellularized human compare them those normal breast tissue. To influence depot source on resultant scaffolds, we performed indentation tests DAT samples sourced from isolated breast, subcutaneous abdominal region, omentum, pericardial thymic remnant, their corresponding force–displacement data were acquired. Elastic parameters estimated using inverse finite element algorithms. Subsequently, simulation conducted which tested real model under gravity loading order suitability scaffolds implantation. Results these showed that would show similar deformability native Using measured parameters, able whether derived different depots exhibited intrinsic nonlinearities. varying regions body little nonlinearity, with no statistically significant differences between groups.