作者: Joon-Ho Yu , Paul S Appelbaum , Kyle B Brothers , Steven Joffe , Tia L Kauffman
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摘要: Implementing genome and exome sequencing in clinical practice presents challenges, including obtaining meaningful informed consent. Consent may be challenging due to test limitations such as uncertainties associated with results interpretation, complexity created by the potential for additional findings high patient expectations. We drew on experiences of research teams within Clinical Sequencing Exploratory Research (CSER1) Consortium consent (CGES) negotiate consensus considerations. present six considerations clinicians 12 key points communicate they support patients deciding whether undergo CGES. These provide a helpful starting point CGES, grounded experience.