Pathogenic factors in aminoglycoside-induced nephrotoxicity.

摘要: Abstract Aminoglycoside antibiotics play an integral role in antimicrobial chemotherapy. Unfortunately, these drugs are known to cause nephrotoxicity man and experimental animals. In fact, the incidence of renal dysfunction during course clinical treatment with aminoglycoside is approximately 10%. Over past two decades elucidation pathogenesis aminoglycoside-induced has been subject numerous investigations. This review describes recent theories postulated a antibiotic-induced damage. particular, importance levels cortex or at membrane binding site examined detail. The relevance antibiotic tissue reflected ability other modify through alteration content. factors including age diet drug-induced described. practice, may often be administered conjunction agents. influence interaction vancomycin, cephalosporins cytotoxic light reports that potentiated situations. addition, this focuses on infection (pyelonephritis septicemia) bacterial endotoxin as pathogenic involved nephrotoxicity. Both direct indirect effects vasoactive mediators inflammatory processes will discussed. A multiplicity further amplified presence infection.