Adaptation of O2 transport and utilization at altitude in man.

摘要: The mammalian O2 transport system is remarkable in at least two major respects. First, several organs must work together an integrated manner to achieve maximal rates of transfer from inspired air muscle mitochondria during exercise. Too little or too much functional ability one organ compared another produces inefficiency. For example, a high cardiac output clearly enhances the bulk between lungs and muscle, but if high, both diffusive loading lung unloading tissues are compromised by rapid red cell transit times. Thus, pulmonary (using convective modes transport) linked cardiovascular system, which turn delivers dependent on blood (Hb concentration, shape position Hb dissociation curve) capacity diffusion mitochondrion. second aspect that exercise, virtually all can be transferred into arterial able extracted used exercising muscles. In trained normal subjects, extraction exceed 90%.