Determination of Solubility Parameters of Ibuprofen and Ibuprofen Lysinate

摘要: In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable problem by these dispersions is drug-carrier (in)solubility. Here we focus on parameters as tool for predicting the of certain carriers. Solubility were determined two different ways: solely using calculation methods, experimental approaches. Six methods applied order to calculate ibuprofen several excipients. However, not able do so case lysinate, models salts are still defined. Therefore, extended Hansen’s approach inverse gas chromatography (IGC) used evaluating lysinate. obtained values total parameter did differ much between methods: it was δt = 31.15 MPa0.5 with IGC 35.17 MPa0.5. partial parameters, i.e., δd, δp δh, from each other, what might be due complex behaviour salt presence various solvents.