Hot-melt extrusion with poorly soluble drugs

摘要: Hot-melt extrusion with poorly soluble drugs is a challenging method to enhance solubility. The formation of solid dispersions leads metastable systems that have advantageous dissolution behaviour. hot-melt process influenced by several parameters. right coordination the parameters decisive for production and thus, success in solubility enhancement. Besides configuration screw temperature profile barrel, design die plate represents third important parameter. Basic butylated methacrylate copolymer suitable carrier water-soluble drug celecoxib process. best enhancement can be obtained dispersing molten on molecular basis form glassy solutions. Glassy solutions basic fast rate result 58 fold supersaturated solution. mechanism release from these carrier-controlled governed dissolution. based improved wettability. highly dependent physicochemical properties compounds their miscibility state. use as enhancing cannot transferred all drugs. Thus, each formulation has analyzed separately. A combined approach tools predicting appropriate, no single technique may yield required information. Nevertheless, evaluation melting behaviour via DSC highest impact. extruded processed into dosage forms. mechanical energy input through milling tabletting influence solid-state stability. solution-state stability achieved adding HPMC external phase. filling capsules milled extrudates promising obtain forms solutions. By extensive analysis process, interactions compounds, thermal characteristics, resulting systems, it possible predict an early stage development improve