Melt Extruded Controlled Release Dosage Forms
作者： Justin M. Keen , James W. McGinity
DOI: 10.1007/978-1-4614-8432-5_10
关键词: Chemical engineering 、 Controlled release 、 Pellets 、 Drug release 、 Dosage form 、 Drug 、 Patient compliance 、 Bioavailability 、 Materials science 、 Extrusion
摘要: Hot-melt extrusion is a proven pharmaceutical processing technology, enabling the formation of matrices and structures designed to control drug release. Controlled release formulations are important for reducing side effects, improving bioavailability, patient compliance. Melt has been applied in production various controlled-release dosage forms: including pellets, tablets, films, reservoirs. Controlled-release forms prepared by have demonstrated oral delivery as well producing implants transmucosal devices. This chapter reviews extruded forms, highlighting importance material properties structure. The mechanisms which drugs released from different materials reviewed using examples current literature.
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