Physicochemical characterization and mechanisms of release of theophylline from melt-extruded dosage forms based on a methacrylic acid copolymer
作者： Christopher R. Young , Caroline Dietzsch , Matteo Cerea , Thomas Farrell , Kurt A. Fegely
DOI: 10.1016/J.IJPHARM.2005.05.025
关键词: Chemical engineering 、 Controlled release 、 Dosage form 、 Organic chemistry 、 Thermogravimetric analysis 、 Hypromellose Derivatives 、 Extrusion 、 Chemistry 、 Triethyl citrate 、 Excipient 、 Solubility
摘要: The purpose of the current study was to investigate physicochemical properties melt-extruded dosage forms based on Acryl-EZE and determine influence gelling agents mechanisms kinetics drug release from thermally processed matrices. is a pre-mixed excipient blend methacrylic acid copolymer that optimized for film-coating applications. Powder blends containing theophylline, Acryl-EZE, triethyl citrate an optional agent, Methocel K4M Premium (hydroxypropyl methylcellulose, HPMC, hypromellose 2208) or Carbopol 974P (carbomer), were using Randcastle single-screw extruder. physical chemical stability materials during processing determined thermal gravimetric analysis HPLC. mechanism Korsmeyer-Peppas model hydration erosion tablets dissolution studies investigated. physically chemically stable processing, resulting exhibited pH-dependent properties. Extrusion HPMC carbomer changed forms. At concentrations 5% below, more effective than at extending duration theophylline matrix tablets. Furthermore, upon storage 3 months 40 degrees C/75% RH. Thus, hot-melt extrusion process preparation controlled systems Acryl-EZE.
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