Amino acids transitioning of 2009 H1N1pdm in Taiwan from 2009 to 2011.

摘要: A swine-origin influenza was detected in April 2009 and soon became the H1N1 pandemic strain (H1N1pdm). The current study revealed genetic diversity of H1N1pdm, based on 77 70 isolates which we collected, respectively, during 2009/2010 2010/2011 seasons Taiwan. We focused tracking amino acid transitioning hemagglutinin (HA) neuraminidase (NA) genes early diversification virus compared them with H1N1pdm strains reported worldwide. identified newly emerged mutation markers A/California/04/2009, described how these shifted from first season to one that immediately followed, discussed observations may relate antigenicity, receptor-binding, drug susceptibility. It found rates were elevated, 9.29×10−3 substitutions per site 1.46×10−2 second HA, 5.23×10−3 1.10×10−2 NA. Many season, including 11 HA 8 NA, some having statistical correlation disease severity. There five noticeable mutations made antigenic sites. No significant titer changes, however, hemagglutination inhibition tests. Only isolate H275Y known reduce susceptibility NA inhibitors detected. As limited Taiwanese viruses isolated after our sampling period, gathered 8,876 6,017 sequences up 2012 NCBI follow dynamics mentioned mutations. While this seemed either settle or die out 2011–2012 a number still showed signs transitioning, prompting importance continuous monitoring for more come.