NSAID-behandling av osteoartrit hos hund
作者： Sanna Andersson
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摘要: Osteoartrit ar en vanligt forekommande sjukdom hos vara hundar som associeras med kronisk smarta. Som behandling mot smartan anvands ofta non-steroid antiinflammatory drugs (NSAID) hammar enzymet cyklooxygenas (COX). De traditionella NSAID-preparaten har vid langtidsbehandling gett upphov till allvarliga biverkningar sasom mag- och tarmslemhinneskador. Upptackten av de tva isoenzymerna COX1, uttrycks kontinuerligt i alla vavnader, COX2 vissa vavnader samt uppregleras inflammation, ledde till utvecklingen coxiberna. Det typ NSAID utvecklades intentionen att minska biverkningsfrekvensen genom selektivt inhibera COX2. I nulaget det inte helt klart hur skiljer sig mellan selektiva oselektiva COX2-hammare. Firocoxib coxib jamforande studier har visats ha fordelar bade lagre frekvens tarmbiverkningar battre smartlindringsresultat an traditionella NSAID. finns aven indikationer pa mavacoxib, ocksa coxib, dessa egenskaper men dess ovanligt langa halveringstid gor anvandningen komplicerad ur biverkningssynpunkt. kan tankas coxiber orsakar andra sorters COX-hammare da framfor allt hjart- karlbiverkningar observerats inom humanmedicinen. I dock inga tecken hund.
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