A glycoporphyrin story: from chemistry to PDT treatment of cancer mouse models
作者： M. Lupu , Ph. Maillard , J. Mispelter , F. Poyer , C. D. Thomas
DOI: 10.1039/C8PP00123E
关键词:
摘要: Photodynamic therapy (PDT) represents a non-toxic and non-mutagenic antitumor therapy. The photosensitizer's (PS) chemo-physical properties are essential for the therapy, being responsible biological effects induced in targeted tissues. In this study, we present synthesis development of some glycoconjugated porphyrins based on lectin-type receptor interaction. They were tested vitro finally choosing most effective chemical structure an optimum outcome. photosensitizer is substituted by three diethylene glycol α-d-mannosyl groups. vivo studies allow firstly determination characteristics processes triggered initial photochemical activation. Secondly, they make it possible to improve therapeutic protocol function structural architecture tumor tissue.
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