Exclusion of deep venous thrombosis with D-dimer testing--comparison of 13 D-dimer methods in 99 outpatients suspected of deep venous thrombosis using venography as reference standard.

摘要: In a direct assay comparison we evaluated the diagnostic performance of 10 novel D-Dimer assays for exclusion deep venous thrombosis (DVT). addition, 3 conventional ELISA were included as reference tests. The study was performed in 99 consecutive outpatients referred to emergency department clinical suspicion DVT. Venography used standard and demonstrated presence DVT 50 patients (6 with isolated distal 44 proximal DVT). qualitative Minutex SimpliRED quantitative BC DD showed overall sensitivities (for DVT) only 80-83% specificities that ranged from 87 94%. Overall sensitivity 94% INSTANT I.A. 98% Turbiquant at cut-off level equal detection limit. Using different levels 100% well could be obtained NycoCard, IL DD, Liatest, Tinaquant VIDAS 31% (NycoCard) 71% (VIDAS) 12% 47% (IL DD) At upper limit range specificity 39% 41% respectively. results this suggest have highest outpatients. low or moderate pretest probability DVT, these tests may management studies where anticoagulation is withheld on basis testing alone.