Interactions of tumour-targeting nanoparticles with proteins: potential of using capillary electrophoresis as a direct probe.

摘要: Metal-based nanoscale particles possess unique optoelectronic or magnetic properties that make them highly promising as imaging agents in cancer therapy research. The fate of nanoparticles vivo and particularly, the delivery to tumours are closely related their interactions with plasma proteins. Furthermore, proteins can be used modify nanoparticle surface order facilitate active targeting tumours. Therefore, there is an ongoing need for new more capable analytical methodologies characterize protein–nanoparticle binding. Due small-sample volume requirement, high degree resolution and, most importantly, mild, species-friendly separation conditions, capillary electrophoresis (CE) gaining increasing popularity analysis interaction. This perspective article highlights potential CE studying reactions associated protein-mediated transformations nanoparticles, focus on quantum dots, gold iron oxide nanoparticles. Different ways by which applied such monitoring summarized critically assessed using a representative coverage recent publications.