Prognostic Value of Biochemical Recurrence Following Treatment with Curative Intent for Prostate Cancer: A Systematic Review

摘要: Abstract Context In men with prostate cancer (PCa) treated curative intent, controversy exists regarding the impact of biochemical recurrence (BCR) on oncological outcomes. Objective To perform a systematic review existing literature BCR after treatment intent for nonmetastatic PCa. 1 is to investigate whether outcomes differ between patients or without BCR. 2 study which clinical factors and tumor features in have an independent prognostic Evidence acquisition Medline, Medline In-Process, Embase, Cochrane Central Register Controlled Trials were searched. For objective 1, prospective retrospective studies comparing survival following radical prostatectomy (RP) radiotherapy (RT) included. 2, all at least 100 participants reporting patient characteristics Risk-of-bias confounding assessments performed according Quality Prognosis Studies tool. Both narrative synthesis meta-analysis undertaken. Overall, 77 included analysis, 14 addressed recruiting 20 406 patients. was by 71 29 057, 11 301, 4272 undergoing RP, RT, mixed population (mix RP RT as primary treatment), respectively. There low risk bias participation, confounders, statistical analysis. most studies, attrition bias, outcome measurements not clearly reported. associated worse rates, mainly short prostate-specific antigen doubling time (PSA-DT) high final Gleason score interval failure (IBF) biopsy score. Conclusions has survival, but this effect appears be limited subgroup specific factors. Short PSA-DT IBF are main that negative survival. These may form basis new stratification (European Association Urology Risk Groups), needs validated formally. Patient summary This looks death who shows rising (PSA) blood test surgery radiotherapy. many men, PSA does mean they from longer term. Men rises shortly rapidly grade both modalities highest death.