Randomised study of risk of fetal loss related to early amniocentesis versus chorionic villus sampling

摘要: Summary Background Several cohort studies have shown the feasibility of early amniocentesis (between 11 and 13 weeks gestation) as an alternative to chorionic villus sampling (CVS) for karyotyping, but only completed randomised study fetal safety showed a significant fetal-loss risk related first-trimester amniocentesis. We assessed in CVS. Methods at 11–13 weeks' gestational age compared with associated CVS 10–12 weeks. 1160 pregnant women were randomly assigned one procedure (581 amniocentesis, 579 CVS) after baseline ultrasound examination 10 gestation followed up until birth. Total loss neonatal morbidity primary outcome measures. Sampling success pregnancy complications secondary outcomes. used filter increase cell yield amniotic-fluid samples. was transabdominal. Findings found significantly increased occurrence talipes equinovarus group (p Interpretation Even though numbers small, we association between equinovarus. believe this be true, since it supports trend similar study. Our results show that when done technique, is abortion CVS, although limited size our population reduced strength conclusion.