Polysaccharide-Degrading Phages

摘要: This chapter discusses some of the recent developments and ideas focuses on phages that possess virion-bound capsule depolymerization activities rather than those simply bind to surface carbohydrate structures. The best-characterized polysaccharide-degrading are infect various strains Escherichia coli. Polysaccharide-degrading were also isolated from other gram-negative bacteria, in case Klebsiella, a tremendous amount diversity was found. Probably most structurally characterized extracellular phage tail protein is lysogenic Salmonella P22 tailspike. crystal structures both catalytic domain head-binding have been solved. P22, Sf6, related lysogenic, very little biological or sequence relationship SP6 group, based their structures, may be categorized as own distinct group. We find multispecific encoding more one fairly widespread. While much this work can done by use molecular techniques, typing still rapid reliable method for identifying capsular antigens. In study, endosialidase (endo E) used an antibacterial treat infections E. coli 1 strains. Phages long known play role bacterial pathogenesis transducing virulence factors such toxin genes.