Assessment of fracture risk in a cohort of Egyptian female Systemic Lupus erythematosus patients

摘要: Abstract Aim of the work To assess fracture risk in a cohort Egyptian systemic lupus erythematosus (SLE) females correlation to some disease variables. Patients and methods Seventy female SLE patients ≥40 years old were enrolled with detailed history taking, assessment activity damage index. Measurement S erum calcium, phosphorus alkaline phosphatase, bone mineral density (BMD) by dual emission X-ray absorptiometry (DEXA) at lumbar spine (LS) femoral neck (FN), serum osteocalcin level World Health Organization (WHO) tool (FRAX®). Results 20% had LS osteoporosis, 35.7% osteopenia, 8.6% FN 42.9% osteopenia. Ten-year major hip fractures was high evidenced FRAX-Major ≥20% 10% patients, FRAX-Hip ≥3% 27.1% patients. Serum significantly decreased lower BMD than those normal BMD, osteoporosis A significant negative found between age duration, index scores, current intravenous pulse cumulative steroids, immunosuppressants, anticoagulants, but there positive antimalarials calcium supplements. Conclusion Increasing age, anti-DNA titres, higher associated risk. FRAX predicted among low mass not just frank osteoporosis. Physicians should be alerted future for periodic monitoring.