Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias

摘要: Aging within the human hematopoietic system associates with various deficiencies and disease states, including anemia, myeloid neoplasms reduced adaptive immune responses. Similar phenotypes are observed in mice have been linked to alterations arising at stem cell (HSC) level. Such an association is, however, less established hematopoiesis prompted us here detail characteristics of most primitive compartments throughout ontogeny. In addition, we also attempted interrogate similarities between aging murine hematopoiesis. Coupled transition from cord blood (CB) young aged bone marrow (BM), a gradual increase frequency candidate HSCs. This was accompanied by functional impairments, decreased lymphoid output proliferative potential. Downstream HSCs, decreasing levels common progenitors (CLPs), increasing frequencies megakaryocyte/erythrocyte (MEPs) age, which could be changes lineage-affiliated gene expression patterns These findings were paralleled mice. Therefore, our data support notion that age-related involve HSC pool, prominent skewing towards megakaryocytic/erythroid lineages, suggests conserved mechanisms underlying system.