作者: Alexander Domnich , Donatella Panatto , Eva Klementievna Arbuzova , Alessio Signori , Ulderico Avio
DOI: 10.4161/HV.29984
关键词:
摘要: Tick-borne encephalitis (TBE) virus, which is usually divided into European, Far Eastern and Siberian subtypes, a serious public health problem in several European Asian countries. Vaccination the most effective measure to prevent TBE; cross-subtype protection elicited by TBE vaccines biologically plausible since all virus subtypes are closely related. This manuscript systematically explores available data on immunogenicity currently Western based subtype. Completed immunization course of 3 doses both determined very high seroconversion/seropositivity rates against among previously flavivirus-naive subjects. All but one study found no statistically significant difference titers neutralizing antibodies strains belonging homologous heterologous subtypes. Pooled analysis randomized controlled trials head-to-head comparison Russian did not reveal differences seroconversion isolates either hemagglutination inhibition (risk ratio = 0.98, p 0.83) or enzyme-linked immunosorbent 0.95, 0.44) assays after 2 vaccine doses. suggests that, regions where heterogeneous population circulates, subtype may be used alongside Studies field effectiveness investigation vaccination failures, especially countries different co-circulate, will further elucidate vaccination-induced protection.