Association between recurrence of sporadic colorectal cancer, high level of microsatellite instability, and loss of heterozygosity at chromosome 18q.

摘要: Microsatellite instability and loss of heterozygosity chromosomes 18q, 8p, 4p are genetic alterations commonly found in colorectal cancer. We investigated whether these markers allow for the stratification patients with Stage II to III cancer into groups different recurrence risks, prognoses. Tumors 113 were evaluated microsatellite by use six markers. Genetic involving each examined association disease recurrences survival. Loss informative 96 percent cases, tumors was associated higher risk overall (P < 0.001), local distant metastases decreased survival = 0.002), disease-free 0.001). The rates among independent chromosome 18q. 8p also a when factors considered individually. In multivariate analysis, only 18q independently 0.001) No correlation observed between rates. However, improved 0.04) longer interval 0.002). Only five cases (16.7 percent) it possible perform resection recurrences; two had tumor. no resect is an marker, which resected can be used predict identified that, even case recurrence, have more favorable prognosis.