Localization of human gene loci using spontaneous chromosome rearrangements in human-Chinese hamster somatic cell hybrids.

摘要: Analysis of human-Chinese hamster somatic cell hybrids with spontaneously derived chromosome structural changes has provided data for the regional and subregional localization gene loci which have previously been assigned to human chromosomes 2, 12, X. Correlation expression complements present in indicates that cytoplasmic malate dehydrogenase (MDH1) locus is 2p23yields2pter region, red acid phosphatase (AcP1) at or adjacent 2p23. The isocitrate (IDH1) 2q11, peptidase B (Pep B) 12q21, lactate (LDH 12q21yiedls12pter glucose-6-phosphate (G6PD) Xq24yieldsXqter phosphoglycerate kinase (PGK), alpha-galactosidase (alpha-gal), hypoxanthine guanine phosphoribosyltransferase (GPRT) are Xp21yieldsXq24 region.