Potential markers of oxidative stress in stroke.

摘要: Free radical production is increased in ischemic and hemorrhagic stroke, leading to oxidative stress that contributes brain damage. The measurement of stroke would be extremely important for a better understanding its pathophysiology identifying subgroups patients might receive targeted therapeutic intervention. Since direct free radicals oxidized molecules the difficult humans, several biological substances have been investigated as potential peripheral markers. Among lipid peroxidation products, malondialdehyde, despite relevant methodological limitations, correlated with size clinical outcome, while F2-isoprostanes appear promising, but they not adequately evaluated. 8-Hydroxy-2-deoxyguanosine has extensively markers DNA damage no study done patients. Also enzymatic nonenzymatic antioxidants proposed indirect them ascorbic acid, alpha-tocopherol, uric superoxide dismutase are related outcome. After critical evaluation literature, we conclude that, an ideal biomarker yet available, balance between by-products organism best approach