The interplay between genotype and gene expression in human brain

摘要: This chapter discusses the interplay between genotype and gene expression in human brain. Molecular studies of pharmacological profiles receptors key brain regions cell types delineate alterations neurotransmission alcoholic Individual variations propensity for damage comorbidity modulate these changes. Receptor subunit composition switching that play central roles killing define likely paths to neuroprotection. Increased glutamate release may enhance excitotoxicity by over-stimulation neurones. A reduction gamma-aminobutyric acid (GABA)-mediated inhibition permissively allow increased efficacy glutamatergic inputs could exacerbate this localized excitotoxicity. Drug dependence is linked mesolimbic/cortical dopamine reward rein-forcement mechanisms. Alcohol activates dopaminergic transmission experimental animals, some drugs reduce alcohol intake. Bromocriptine, aD2 agonist, most effective treating alcoholics who possess DRD2 A1 alleles. It suggested agents interact with GABA are comprised different combinations subunits, which confined discrete regions, show promise development as alcohol-misuse therapeutics.