Effect of co-administration of morphine and nicotine on cardiovascular function in two-kidney one clip hypertensive (2K1C) rats.
作者： Motahareh Zeinivand , Mohammad Reza Rahman , Mohammad Allatavakoli , Ali Shamsizadeh , Gholamhossin Hassanshahi
关键词:
摘要: Cardiovascular morbidity and mortality are potentiated with smoking hypertension. The aim of this study was to investigate the effects morphine nicotine co-administration on cardiovascular function in two-kidney one-clip hypertensive (2K1C) rats. Thirty-two male rats were divided into four groups as follow: Vehicle, morphine, + morphine. All drugs administered for 8 weeks. Baroreflex sensitivity (BRS), heart rate blood pressure measured using a Power Lab data acquisition. Plasma rennin activity (PRA) serum concentration nitric oxide (NO) Elisa method. To induce hypertension, renal artery left kidney clipped A significant decrease systolic (SBP), diastolic (DBP) mean arterial (MAP) observed group compared vehicle (p<0.05). Serum NO lower significantly higher than group. BRS other groups. PRA level but it This demonstrated that prolonged co-consumption nicotinedecreased increased Co-administration decreased 2kic probably via central nervous system.
core.ac.uk
bjbms.org
sci-hub.st 参考文章(31)
T B McCall, N K Boughton-Smith, R M J Palmer, B J R Whittle, S Moncada, Synthesis of nitric oxide from l-arginine by neutrophils. Release and interaction with superoxide anion Biochemical Journal. ,vol. 261, pp. 293- 296 ,(1989) , 10.1042/BJ2610293
S. V. Nicosia, R. F. Nicosia, M. Smith, Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro. American Journal of Pathology. ,vol. 145, pp. 1023- 1029 ,(1994)
C.L. Thurston, A. Starnes, A. Randich, Changes in nociception, arterial blood pressure and heart rate produced by intravenous morphine in the conscious rat Brain Research. ,vol. 612, pp. 70- 77 ,(1993) , 10.1016/0006-8993(93)91645-9
Katrina M. Miranda, Michael G. Espey, David A. Wink, A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide. ,vol. 5, pp. 62- 71 ,(2001) , 10.1006/NIOX.2000.0319
M Ashworth-Preece, B Jarrott, A.J Lawrence, Nicotinic acetylcholine receptors in the rat and primate nucleus tractus solitarius and on rat and human inferior vagal (nodose) ganglia : Evidence from in vivo microdialysis and [125I]α-bungarotoxin autoradiography Neuroscience. ,vol. 83, pp. 1113- 1122 ,(1998) , 10.1016/S0306-4522(97)00476-4
O N Niedermaier, M L Smith, L A Beightol, Z Zukowska-Grojec, D S Goldstein, D L Eckberg, Influence of cigarette smoking on human autonomic function. Circulation. ,vol. 88, pp. 562- 571 ,(1993) , 10.1161/01.CIR.88.2.562
Michael Klagsbrun, Patricia A. D'Amore, Vascular endothelial growth factor and its receptors. Cytokine & Growth Factor Reviews. ,vol. 7, pp. 259- 270 ,(1996) , 10.1016/S1359-6101(96)00027-5
Cristina Giannattasio, Arduino A. Mangoni, Maria L. Stella, Stefano Carugo, Guido Grassi, Giuseppe Mancia, Acute effects of smoking on radial artery compliance in humans Journal of Hypertension. ,vol. 12, pp. 691- 696 ,(1994) , 10.1097/00004872-199406000-00009
Noboru Toda, Shiroh Kishioka, Yoshio Hatano, Hiroshi Toda, David S. Warner, Mark A. Warner, Modulation of Opioid Actions by Nitric Oxide Signaling Anesthesiology. ,vol. 110, pp. 166- 181 ,(2009) , 10.1097/ALN.0B013E31819146A9
Jeffrey B. Lakier, Smoking and cardiovascular disease The American Journal of Medicine. ,vol. 93, ,(1992) , 10.1016/0002-9343(92)90620-Q