A missing link between RON expression and oncological outcomes in resected left-sided pancreatic cancer

摘要: Alteration and activation of recepteur d'origine nantais (RON) expression is known to be associated with cancer progression decreased survival in various types human cancer, including pancreatic cancer. Therefore, the present study, RON levels were determined resected left-sided evaluate potential oncological role clinical setting distal From January 2005 December 2011, a total 57 patients underwent radical pancreatectomy for Ductal adenocarcinoma was confirmed all patients. Among these patients, 17 who received preoperative neoadjuvant treatment 7 without available paraffin-embedded tissue blocks excluded from study. cell lines ASPC-1, BxPC-3, MiaPaCa-3 Panc-1, as well specimens by Western blot analysis. vascular endothelial growth factor (VEGF) overexpression also evaluated immunohistochemistry using pre-diluted anti-RON anti-VEGF antibodies. An association identified between outcome overexpression. Increased observed two lines, AsPC-1 BxPC-3. detected 15/33 (45.5%) immunohistochemistry. No significant VEGF (25.5 vs. 87.9%; P=0.667). differences disease-free or disease-specific identified. Although results previous studies have suggested that target study no any adverse effect