Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating β-catenin/SIX1 signaling pathway in gastric cancer

摘要: Recepteur d'origine nantais (RON) has been implicated in cell proliferation, metastasis, and chemoresistance of various human malignancies. The short-form RON (sf-RON) encoded by transcripts was overexpressed gastric cancer tissues, but its regulatory functions remain illustrated. Here, we found that sf-RON promoted proliferation enhancing glucose metabolism. Furthermore, proved to induce the β-catenin expression level through AKT1/GSK3β signaling pathway. Meanwhile, binding sites were identified promoter region SIX1 it also demonstrated positively regulated expression. enhanced activity key proteins metabolism, such as GLUT1 LDHA. Results indicated metabolism participating a sf-RON/β-catenin/SIX1 axis had significant implications for choosing therapeutic target cancer.