Extended vs Short-term Buprenorphine-Naloxone for Treatment of Opioid-Addicted Youth

摘要: Context The usual treatment for opioid-addicted youth is detoxification and counseling. Extended medication-assisted therapy may be more helpful. Objective To evaluate the efficacy of continuing buprenorphine-naloxone 12 weeks vs youth. Design, Setting, Patients Clinical trial at 6 community programs from July 2003 to December 2006 including 152 patients aged 15 21 years who were randomized or a 14-day taper (detox). Interventions in 12-week group prescribed up 24 mg per day 9 then tapered week 12; detox 14 14. All offered weekly individual Main Outcome Measure Opioid-positive urine test result 4, 8, 12. Results number younger than 18 was too small analyze separately, but overall, had higher proportions opioid-positive results 4 8 not (χ 2  = 4.93, P = .09). At 28 positive (61%; 95% confidence interval [CI] = 47%-75%) (26%; CI = 14%-38%). 22 (54%; CI = 38%-70%) (23%; CI = 11%-35%). 12, (51%; CI = 35%-67%) (43%; CI = 29%-57%). By 16 78 (20.5%) remained 52 74 (70%; χ 1  = 32.90, P   = 18.45,  = 6.00, P = .01), less nonstudy addiction  = 25.82, Conclusions Continuing with improved outcome compared short-term detoxification. Further research necessary assess safety longer-term buprenorphine young individuals opioid dependence. Trial Registration clinicaltrials.gov Identifier: NCT00078130