Formation of biocompatible polymer microspheres for controlled drug delivery by a supercritical antisolvent technique

摘要: Publisher Summary The chapter focuses on the hyaluronic acid benzylic ester (HYAFF) polymers. production of polymeric HYAFF microspheres loaded with pharmaceutical is currently performed by solvent–emulsion precipitation. discusses particles through a batch supercritical anti-solvent process (SAS) technique. coprecipitation drugs within polymer examined in chapter. A CO 2 -based technique applied to produce biocompatible form microspheres. With SAS carried out mode, micronic are obtained narrow particle size distribution. experimental apparatus easy-to-use and purification precipitated solid from solvent can be achieved suitably increasing time for removing. possibility obtain full solvent-free product, controlling same dimension particles, probably most important feature when substances used. In process, fluid (SCF) used as antisolvent.