Controlled release system formed by supercritical anti-solvent coprecipitation of a herbicide and a biodegradable polymer
作者： S Taki , E Badens , G Charbit
DOI: 10.1016/S0896-8446(01)00076-6
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摘要: Abstract Coprecipitation using a supercritical antisolvent technique seems to be promising way for the elaboration of controlled herbicide delivery system since it allows preparation (diuron) loaded in amorphous microparticles biodegradable polymer ( l -polylactic acid, -PLA). was successfully realized methylene chloride. The concentrations two components had major influence upon morphology and shape final product. Spherical particles -PLA entrapping diuron were obtained provided that initial did not exceed, respectively 3 wt.% 0.1 chloride at 10 MPa 308 K. A parallel study precipitation by SAS process showed formation long needle-like crystals with mean length 500 μm. time being very short during process, growth rates observed are 10 000 times higher than aqueous solution.
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