Facile Synthesis of Radial-Like Macroporous Superparamagnetic Chitosan Spheres with In-Situ Co-Precipitation and Gelation of Ferro-Gels

摘要: Macroporous chitosan spheres encapsulating superparamagnetic iron oxide nanoparticles were synthesized by a facile and effective one-step fabrication process. Ferro-gels containing ferrous cations, ferric cations dropped into sodium hydroxide solution through syringe pump. In addition, was employed for both gelation (chitosan) co-precipitation (ferrous cations) of the ferro-gels. The results showed that in-situ ferro-ions gave rise to radial morphology with non-spheroid macro pores (large cavities) inside spheres. particle size can be adjusted from 2.5 nm 5.4 tuning concentration solution. Using Fourier Transform Infrared Spectroscopy X-ray diffraction spectra, illustrated as Fe3O4 nanoparticles. prepared macroporous presented super-paramagnetic behaviour at room temperature saturation magnetization value high ca. 18 emu/g. cytotoxicity estimated using cell viability incubating doses (0∼1000 µg/mL) result good (above 80%) alginate particles below 1000 µg/mL, indicating potentially useful biomedical applications in future.