Stabilization of cytochrome p450j messenger ribonucleic acid in the diabetic rat
作者： Byung J. Song , Tamihide Matsunaga , James P. Hardwick , Sang S. Park , Richard L. Veech
DOI: 10.1210/MEND-1-8-542
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摘要: Cytochrome P450j, an enzyme involved in nitrosamine metabolism, is expressed hepatic, pulmonary, and renal tissues its level elevated ethanol- acetone-treated rats as well diabetic induced by either streptozotocin or alloxan. Although P450j protein substantially all inducing regimens, only mRNA increased 10-fold. Nuclear run-on transcription analysis showed that this increase not due to transcriptional activation but specific stabilization of the mRNA.
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