Effects of pyrazole on nitrosodimethylamine demethylase and other microsomal xenobiotic metabolising activities

摘要: Abstract Pyrazole administered to immature rats at one day or on four successive days prior sacrifice increased a microsomal NDMAD with apparent K m 0.04 mM. Aniline hydroxylase activity was also by these treatments. Ethoxycoumarin deethylase and amino pyrine demethylase activities were not altered when animals treated pyrazole but reduced below control for days. All monooxygenases decreased received single administration of the cytochrome P-450 content microsomes up 50%. When from untreated incubated in presence NADPH, time dependent process limiting value. The effect concentration saturable. These results suggest that induces isoenzyme high affinity NDMA acts as suicide inhibitor cytochrome.