Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells
作者： Jian Guan , Hui Zhang , Zhang Wen , Yumei Gu , Yin Cheng
DOI: 10.1016/J.CANLET.2013.12.006
关键词:
摘要: Retinoic acid (RA) is a small molecular derivative of vitamin A that stored in quiescent stellate cells pancreas stroma. Cancer associated fibroblasts (CAFs) are activated fibroblast pancreatic ductal adenocarcinoma tumor microenvironment. We treated CAFs with RA and found these became static due to the low expression α-SMA, FAP, IL-6 decreased production extracellular matrix (ECM). Furthermore, we verified secretion from was related RA-induced inhibition migration epithelial-mesenchymal transition (EMT) cells. However, could not inhibit EMT directly. Therefore, our study showed one therapeutic effects on through its modulation The microenvironment plays an important role promoting might be promising target biological treatment.
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Minoti V Apte, Jeremy S Wilson, Dangerous liaisons: pancreatic stellate cells and pancreatic cancer cells. Journal of Gastroenterology and Hepatology. ,vol. 27, pp. 69- 74 ,(2012) , 10.1111/J.1440-1746.2011.07000.X
Max G. Bachem, Marion Schünemann, Marco Ramadani, Marco Siech, Hans Beger, Andreas Buck, Shaoxia Zhou, Alexandra Schmid-Kotsas, Guido Adler, Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells Gastroenterology. ,vol. 128, pp. 907- 921 ,(2005) , 10.1053/J.GASTRO.2004.12.036
F Pettersson, A G Dalgleish, R P Bissonnette, K W Colston, Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-γ and altered expression of Bcl-2/Bax British Journal of Cancer. ,vol. 87, pp. 555- 561 ,(2002) , 10.1038/SJ.BJC.6600496
N J Sullivan, A K Sasser, A E Axel, F Vesuna, V Raman, N Ramirez, T M Oberyszyn, B M Hall, Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene. ,vol. 28, pp. 2940- 2947 ,(2009) , 10.1038/ONC.2009.180
George Leef, Sufi Mary Thomas, Molecular communication between tumor-associated fibroblasts and head and neck squamous cell carcinoma Oral Oncology. ,vol. 49, pp. 381- 386 ,(2013) , 10.1016/J.ORALONCOLOGY.2012.12.014
Gloria De Carlo Massaro, Donald Massaro, Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats Nature Medicine. ,vol. 3, pp. 675- 677 ,(1997) , 10.1038/NM0697-675
Alexander Endler, Li Chen, Qin Li, Kazuyo Uchida, Takuya Hashimoto, Lixia Lu, Guo-Tong Xu, Futoshi Shibasaki, Int6/eIF3e silenced HIF2α stabilization enhances migration and tube formation of HUVECs via IL-6 and IL-8 signaling Cytokine. ,vol. 62, pp. 115- 122 ,(2013) , 10.1016/J.CYTO.2013.01.021
M. V. Apte, S. Park, P. A. Phillips, N. Santucci, D. Goldstein, R. K. Kumar, G. A. Ramm, M. Buchler, H. Friess, J. A. McCarroll, G. Keogh, N. Merrett, R. Pirola, J. S. Wilson, Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas. ,vol. 29, pp. 179- 187 ,(2004) , 10.1097/00006676-200410000-00002
Daruka Mahadevan, Daniel D. Von Hoff, Tumor-stroma interactions in pancreatic ductal adenocarcinoma Molecular Cancer Therapeutics. ,vol. 6, pp. 1186- 1197 ,(2007) , 10.1158/1535-7163.MCT-06-0686
Misako Shibakura, Kenji Niiya, Toru Kiguchi, Katsuji Shinagawa, Fumihiko Ishimaru, Kazuma Ikeda, Masayoshi Namba, Yasunari Nakata, Mine Harada, Mitsune Tanimoto, Simultaneous induction of matrix metalloproteinase‐9 and interleukin 8 by all‐trans retinoic acid in human PL‐21 and NB4 myeloid leukaemia cells British Journal of Haematology. ,vol. 118, pp. 419- 425 ,(2002) , 10.1046/J.1365-2141.2002.03723.X