Retrieval of morphine-associated context induces cFos in dentate gyrus neurons

摘要: Addiction has been proposed to emerge from associations between the drug and reward-associated contexts. This associative learning a cellular correlate, as there are more cFos+ neurons in hippocampal dentate gyrus (DG) after psychostimulant conditioned place preference (CPP) versus saline controls. However, it is unknown whether morphine CPP leads similar DG activation, or activation due locomotion, handling, pharmacological effects, or-as data contextual fear suggests-exposure drug-associated context. To explore this, we employed an unbiased, counterbalanced, shortened design that led cells. Next, mice underwent but were then sequestered into morphine-paired (conditioned stimulus+ [CS+]) saline-paired (CS-) context on test day. Morphine-paired CS+ had ∼30% cells than mice. Furthermore, Bregma analysis revealed compared CS- Notably, was no significant difference cell number handling alone receiving home cage. Thus, retrieval of morphine-associated accompanied by granule neurons.